The Aseptic Transfer Isolator (AP-IS Series) is specifically designed to comply with the needs of liquid material transfer from a Class A environment to any external fluid collector tank.
The Aseptic Transfer Isolator is a brand new custom isolator system for pharmaceutical companies requiring a low rH% value aseptic environment for the transfer of liquid substances.
This isolator is composed of a single working chamber, integrated with our HYPER bio-decontamination system and monitoring detectors for H2O2 levels, a Rapid Transfer Port DPTE®, a SART® port and a Flexicon® peristaltic pump.
Liquid transfer is the main requirement; it should however be also considered that the very substances entering the isolator have different temperatures, mostly very low, around 0°C.
After the bio-decontamination cycle with VPHP (which acts at a temperature of about 35-40°C), a relevant peroxide residue is expected to affect both the isolator and its load. For viruses used for the development of vaccines, getting in contact with condensed VPHP is enough for the whole process to be jeopardized.
A solution was found by developing an advanced ventilation system with an integrated dehumidification unit. Upon completion of the bio-decontamination cycle, a flow of conditioned hot air runs through the chamber (at very low relative humidity and high flow rate), which dries and quickly removes the residual H2O2 up to the threshold value of 1 ppm.
An easy and customized workflow for the operator
The workflow has been designed to meet the strict needs of the customer, and structured to make each phase as simple as possible. Our know-how and the high engineering value of our isolators allow us integrations and customizations pliable to all types of aseptic processes.
It takes just 6 steps to carry out a single cycle of this process: